3D Printing and Nanosensor Technology for Early Stage Disease Detection

Detection strategies based on nanowire offer a promising new route towards rapidly detecting diseases such as cancer. I recently reported on the successfully integration of 3D printed components with nanosensor technology in the medical journal, Point-of-Care.  The article had the catchy title, “Fabrication of an integrated 3D printed polymer SiNW-based microfluidic point of care system for detecting 8-OHdG cancer biomarker”.

The fabrication of 200µm width active flow micro-channels by 3D printing methods is an essential component that enables the examination of micro-litre quantities of bodily fluid in non-invasive diagnostic devices. By flexographically printing metal contacts onto 3D printed devices, we were able to subsequently integrate it with a nanosensor chip.

The silicon nanowire-based nanosensor combined to the device was functionalised with 8-hydroxydeoxyguanosine (8-OHdG) antibodies that are used to detect oxidative stress biomarkers linked to the presence of several common cancers. A biomarker is an indicator of a biological state of disease, so they can be used to monitor or recognise disruption or alterations in normal cellular processes. This research fabricated and tested the 3D printed microchannel-based device to detect the presence of 8-OHdG biomarkers, which can be used to indicate the early presence of a range of different cancers.

Read more at ENGINEERING.com

Share on facebook
Share on twitter
Share on linkedin
Share on pinterest

Related Articles

Keep up to date on 3D Printing technologies

We're learning a lot about 3D printing, and So will you.

Subscribe to our mailing list and make better 3D print decisions.