Post-stroke, a patient often loses the ability to move a hand. Rennaker uses his research to simulate this disability with his lab subjects. The subjects place a paw in a hole with a wheel at the bottom, when the subjects rotate the wheel they are given a food reward. The device forces the subject to use its paw instead of its whole leg. The group is studying the effect of stimulating the Vagus nerve while performing the task in an attempt to facilitate and expedite recovery of function in the limb affected by the stroke.